cyclophosphamide will raise the degree or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
This allergic response could be daily life-threatening and might cause Loss of life. Get in touch with your healthcare provider without delay Should you have: a skin rash, hives; fever or swollen glands that don't disappear; swelling of your experience; shortness of breath; swelling on the legs; yellowing of the skin or whites from the eyes; or darkish urine The most typical Unwanted effects of FYCOMPA involve:
modafinil will lower the extent or influence of iobenguane I 131 by Other (see comment). Stay away from or Use Alternate Drug. Determined by the mechanism of motion of iobenguane, medications that minimize catecholamine uptake or that deplete catecholamine shops may interfere with iobenguane uptake into cells, and so, lessen iobenguane efficacy.
When you're getting this medicine, it is very essential that the healthcare Skilled know In case you are using any of your medicines stated down below. The next interactions are picked on The premise of their potential significance and therefore are not always all-inclusive.
Also, your health and fitness treatment Experienced could possibly show you about approaches to avoid or lessen Many of these Unintended effects. Look at with all your wellness care Expert if any of the following side effects more information continue or are bothersome or if you have any questions about them:
Medication that have amount limits connected to Each and every prescription. This restriction generally boundaries the amount of the drug that could be covered.
It was clinically found that modafinil has an effect on pharmacodynamics of medications which might be metabolized by CYP3A4 together with other enzymes of the cytochrome P450 spouse and children, making sure that interactions of modafinil with these medicine were noticed in actual people, in lieu of getting predicted in the lab location.
Keep an eye on the quantity of medication applied from each new bottle. Modafinil is usually a drug of abuse and you need to be knowledgeable if any one is utilizing your medication improperly or with out a prescription.
Major rash requiring hospitalization and discontinuation of therapy has become reported in association with the use of modafinil.
Pregnancy: It is assessed as pregnancy class C drugs by FDA. There's no proof to recommend or exclude hurt towards the human fetus connected with modafinil.
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Modafinil appeared to produce a focus-similar suppression of CYP2C9 exercise, hence suggesting probable for CYP2C9 inhibition; caution if drugs which have a narrow therapeutic index
In addition, it has numerous off-label indications. This activity will emphasize the system of motion, adverse function profile, pharmacology, monitoring, and related interactions of modafinil, pertinent for members of your interprofessional staff from the treatment method of sufferers with circumstances where modafinil has a therapeutic intent.
The exact same can come about with modafinil— Which explains why it’s very best to make sure there isn't any troubles just before jumping straight into a significant 400 mg dosage.